The direct answer
Yes. Hemp-derived Delta-9 THC drinks like NICE contain an active dose of THC, and standard drug tests are generally designed to detect THC or its metabolites. Drinking a NICE can create a real risk of a positive result on a standard THC screen, regardless of the fact that it's hemp-derived rather than marijuana-derived.
Why 'hemp-derived' doesn't change this
Standard drug tests generally aren't built to distinguish between Delta-9 THC that came from hemp and Delta-9 THC that came from a marijuana plant — the molecule and its metabolites are largely what's being detected, not the plant of origin. The legal distinction under the 2018 Farm Bill doesn't translate into a different result on a standard test.
Who should avoid these products entirely
If you're subject to any kind of drug testing — for employment, a safety-sensitive role, a sports or licensing body, probation, or anything similar — the safest approach is to avoid hemp-derived Delta-9 THC drinks entirely rather than assume a single can is 'safe' from a testing standpoint. There's no dose we can point to as guaranteed not to trigger a positive result.
What we can't tell you
We can't give you a specific timeline for how long THC or its metabolites might be detectable for you personally — that depends on factors like frequency of use, individual metabolism, body composition and the specific test being used, none of which we can predict from the outside.
Bottom line
Treat any hemp-derived Delta-9 THC beverage as something that can show up on a drug test, full stop. If that's a risk you can't take, this category — including NICE — isn't for you right now.